Emerald Cloud Lab

Emerald Cloud Lab (ECL) provides a remotely accessible, highly automated life‑science laboratory where researchers design, execute, and analyze experiments through a unified software interface. Built to operate 24/7, ECL consolidates hundreds of bench techniques and more than 200 instrument models under a single command platform so teams can run in‑vitro biology, chemical workflows, and analytics without maintaining their own physical lab. The platform emphasizes reproducibility and data integrity: every method and result is annotated with full metadata to ALCOA+ standards and stored in a growing knowledge graph called ECL Constellation. At the core of the user experience is the ECL Command Center, a browser‑based workspace for experiment design, orchestration, and analysis. Users can interactively run instrument commands, queue parallel experiments, or build larger scripts that route samples across a sequence of operations. The software includes a suite of over 4,500 built‑in functions for plotting, image processing, machine learning, and multidimensional analysis so routine visualization, ELN, LIMS, LES/MES, QMS and many other informatics touchpoints are consolidated into one platform. ECL Constellation automatically saves and links methods, raw data, and processed results into a knowledge graph that grows with every experiment and can be queried to inform future work. The facilities combine robotic workcells, liquid handlers, acoustic dispensers, centrifuges, plate readers, chromatographs, mass spectrometers, NMR, PCR/qPCR/ddPCR systems, flow cytometers/FACS, automated gel and capillary electrophoresis, DLS/SLS, SPR/BLI, peptide/DNA/RNA synthesis, and more. Specific capabilities include microliter to nanoliter dispensing (acoustic ECHO: 2.5 nL–5 µL), multichannel and single‑channel pipetting (1 µL–1 mL), automated positive‑pressure filtration, SPE and preparative HPLC, FPLC/affinity and SEC, GC/MS and LC/MS with high scan speeds, and 1D/2D NMR experiments with multiple probe types. The cloud lab also automates tasks historically considered “manual”—solid handling, rotovaping, speed‑vacing, lyophilization, tablet cutting, and gravimetric transfers—so stock solutions, scale‑up work, and sample prep are scriptable and reproducible. ECL supports diverse workflows from high‑throughput discovery and DoE optimization to CMC, DMPK, and compendial testing. Typical use cases include automated plate‑based biochemical and cell‑based assays using multimode plate readers and incubators (room temp to 45°C with O2/CO2 control), high‑precision compound dispensing for SAR and screening, oligo and peptide synthesis with custom coupling parameters and purification, preparative separations and fraction collection, intact protein and aggregation analysis (DLS/SLS, SEC‑MALS), and multi‑modal analytics combining HPLC, MS, and NMR. Sample logistics allow chilled and frozen handling (marked for -86°C to +105°C where applicable) and both sterile and non‑sterile processing; the platform supports gravimetric transfers from micrograms to kilograms and automated magnetic bead separations and nucleic acid purification. Integration and compliance are central to how ECL surfaces data to users and enterprise systems. Command Center’s native analysis and visualization reduce the need for separate ELN/LIMS/LES stacks, while ECL Constellation preserves method provenance and enforces data integrity for auditability. The platform is positioned to meet the needs of academic labs, startups, large enterprises, and teaching programs: account options range from one‑off runs to subscriptions and dedicated campus or enterprise deployments. To use the service, users ship samples to an Emerald facility, construct protocols in the Command Center, and have experiments executed remotely to specification; results and associated metadata are returned through the platform for downstream analysis and reuse. Emerald Cloud Lab aims to lower barriers to access specialized instrumentation, accelerate iterative experimentation, and shift researcher time from manual bench labor toward design, interpretation, and model‑driven optimization. By combining broad instrumentation, automated manual techniques, programmable workflows, and a unified knowledge graph, ECL is suited for teams that need reproducible, scalable wet‑lab execution and integrated data management without building or staffing their own labs.