Cellario (HighRes Biosolutions)

Background Cellario is HighRes Biosolutions’ laboratory orchestration suite designed to turn fragmented lab instruments and software into a unified automation layer. Built as an API-first, cloud-native platform, Cellario and its core engine CellarioOS connect ELNs, LIMS, instruments and analytics so laboratories can define, schedule and execute science as end-to-end workflows. The platform is modular by design: it supports pre-configured application-ready workcells (ELISA, PCR, screening, sample management) as well as custom “build your own workcell” configurations that combine robotic arms, liquid handlers, storage, and ancillary devices into a single controlled environment. Core capabilities At its heart, Cellario provides orchestration, scheduling and device control. Cellario Scheduler dynamically organizes instruments and resources, manages sample utilization, balances workloads across devices or workcells, and minimizes bottlenecks and downtime. Device-specific CellarioDrivers provide direct control, data collection and error capture from integrated instruments; reservation and collaboration features expose standalone devices, workstations and robotic systems to users in the context of their experiments. The platform also guides operators through manual tasks with digital SOPs and human-in-the-loop steps, allowing workflows to mix automated and manual operations seamlessly. Data and compliance Cellario emphasizes traceability and FAIR data practices. Actions and data produced by devices and workcells are stored with rich metadata (request IDs, device, location, timestamps and external identifiers) and are discoverable via RESTful APIs. Files can be downloaded directly from event entries or linked to customer storage locations using standard transfer protocols. A full event trail records all actions leading to a data point, simplifying contextual validation during analysis or audit. The suite supports compliance features such as audit trails and role controls aligned with FDA 21 CFR Part 11 requirements and provides documentation and developer resources to help customers validate their systems. Example use cases Cellario is used across high-throughput screening, genomics sample prep, synthetic biology DMTA cycles, and cell line development. Typical deployments include automated oligo plating and QC with quantification and normalization across many plates, NGS library preparation with precise liquid handling and scheduling to reduce error rates, and HTS or high-content imaging workflows that require 24/7 operation and tight sample routing. Mobile robotics (AutoPod) extend reach by safely transporting plates and samples between instruments—even across rooms or floors—while integrated high-density storage keeps sample inventories auditable and environmentally controlled. Customers report improved throughput, reduced operator touchpoints, and consistent sample treatment when running complex multi-step assays. Extensibility and integrations Cellario is built for integration. It exposes RESTful APIs and scripting tools (examples in C# and Python) on a developer site that includes documentation and an AI assistant for code snippets and how-to guidance. The platform integrates with a wide ecosystem of informatics and automation partners—examples listed by HighRes include Dotmatics, TetraScience, Titian Mosaic, LabVoice, Scigilian, Splunk, Simplicis Ledger, Virscidian and Xavo R3—enabling data flow between enterprise software and lab automation. Hardware integrations highlighted on the site include HighRes products such as Prime liquid handlers, MicroSpin centrifuges, Precise Drop II dispensers and Nucleus automation hardware, plus third-party devices controlled via CellarioDrivers. Support and deployment models HighRes positions Cellario as suitable for single labs up to global, multi-site enterprises. The product supports both in-lab (on-prem) scheduling and cloud-native orchestration for distributed deployments. HighRes provides end-to-end services from consultation and system design to commissioning, maintenance and training—self-paced training and developer resources are available to accelerate adoption. For regulated environments, HighRes offers guidance on GxP compliance and system validation to ensure a properly governed automation footprint. Summary Cellario is a comprehensive lab orchestration solution focused on connecting instruments, managing resources and preserving the context and integrity of experimental data. By combining dynamic scheduling, device drivers, FAIR-aligned data handling, and a growing partner ecosystem, it helps labs scale throughput, improve reproducibility, and operate across single or multiple sites with traceable, auditable workflows.